Mus101 and homologue thereof
OwnerDavid Moore Glover, Rochele Yamamoto +1inventors
InventorsDavid Moore Glover, Rochele Yamamoto, Daryl Henderson
Life of this patent
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Abstract
Plynucleotides encoding a novel Drosophila gene product designated mus101 and homologues thereof as well as mus101 polypeptides are provided. Polynucleotide probes derived from the nucleotide sequence of mus101 and antibodies that bind to mus101 protein are also provided as well as assays for identifying substances that regulate mus101 function.
Claims23
A polynucleotide encoding mus101 or a homologue thereof.
A polynucleotide selected from:
- (a) polynucleotides comprising the nucleotide sequence set out in SEQ ID No. 1 or the complement thereof.
- (b) polynucleotides comprising a nucleotide sequence capable of hybridising to the nucleotide sequence set out in SEQ ID No. 1, or a fragment thereof.
- (c) polynucleotides comprising a nucleotide sequence capable of hybridising to the complement of the nucleotide sequence set out in SEQ ID No. 1 or a fragment thereof.
- (d) polynucleotides comprising a polynucleotide sequence which is degenerate as a result of the genetic code to the polynucleotides defined in (a), (b) or (c).
A polypeptide which comprises the sequence set out in SEQ ID No 2, or a homologue, variant, derivative or fragment thereof.
An antibody capable of binding the polypeptide of SEQ ID. No. 2 or a fragment thereof.
Use of a mus101 polypeptide or homologue, derivative, variant or fragment thereof in a method of identifying a substance capable of affecting mus101 function.
Use of a mus101 polypeptide or homologue thereof, or fragment in an assay for identifying a substance capable of increasing the susceptibility of a cell to DNA damaging agents.
A method for identifying a substance capable of binding to a mus101 polypeptide or a homologue, derivative, variant or fragment thereof, which method comprises incubating the mus101 polypeptide or homologue, derivative, variant or fragment thereof with a candidate substance under suitable conditions and determining whether the substance binds to the mus101 polypeptide or homologue, derivative, variant or fragment thereof.
A method of treating a tumour which method comprises administering to a patient in need of treatment an effective amount of a substance capable of affecting mus101 function.
A method of increasing the susceptibility of a tumour cell to a DNA damaging agent which method comprises administering to said cell a substance capable of affecting mus101 function.
Dependencies are inferred from the claim text.