Method of testing for psoriasis vulgaris
AssigneeHidetoshi Inoko
InventorsHidetoshi Inoko, Gen Tamiya
Life of this patent
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Abstract
By a detailed analysis of the sequences of the MHC S gene, SEEK1 gene, and HCR gene of Japanese patients with psoriasis and healthy individuals, it was demonstrated that some of the examined polymorphisms significantly correlate with psoriasis in the group of Japanese patients. Based on these correlations, it was demonstrated that psoriasis vulgaris can be detected by analyzing these gene polymorphisms in patients with psoriasis.
Claims7
A primer DNA for detecting psoriasis vulgaris in a patient selected from the group of:
- (a) a primer DNA that hybridizes to a DNA comprising the nucleotide sequence of SEQ ID NO:
- 1 or the complementary strand thereof and which is designed so that the 4040th nucleotide of SEQ ID NO:
- 1 or the corresponding nucleotide on the complementary strand thereof is positioned between the primers;
- (b) a primer DNA that hybridizes to a DNA comprising the nucleotide sequence of SEQ ID NO:
- 2 or the complementary strand thereof and which is designed so that the 6413th nucleotide of SEQ ID NO:
- 2 or the corresponding nucleotide on the complementary strand thereof is positioned between the primers;
- (c) a primer DNA that hybridizes to a DNA comprising the nucleotide sequence of SEQ ID NO:
- 2 or the complementary strand thereof, and which is designed so that the 14378th nucleotide of SEQ ID NO:
- 2 or the corresponding nucleotide on the complementary strand thereof is positioned between the primers;
- and
- (d) a primer DNA that hybridizes to a DNA comprising the nucleotide sequence of SEQ ID NO:
- 3 or the complementary strand thereof and which is designed so that the 6196th nucleotide of SEQ ID NO:
- 3 or the corresponding nucleotide on the complementary strand thereof is positioned between the primers.
A method of testing for psoriasis vulgaris, the method comprising the step of detecting a nucleotide polymorphism selected from the group of:
- (a) a polymorphism involving the 4040th nucleotide of SEQ ID NO:
- 1 or a corresponding nucleotide on a complementary strand thereof;
- (b) a polymorphism involving the 6413th nucleotide of SEQ ID NO:
- 2 or a corresponding nucleotide on a complementary strand thereof;
- (c) a polymorphism involving the 14378th nucleotide of SEQ ID NO:
- 2 or a corresponding nucleotide on a complementary strand thereof;
- and
- (d) a polymorphism involving the 6196th nucleotide of SEQ ID NO:
- 3 or a corresponding nucleotide on a complementary strand thereof.
A DNA for testing for psoriasis vulgaris selected from the group of:
- (a) a part or a whole of a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 1 or the sequence of SEQ ID NO:
- 1 wherein the 4040th nucleotide has been substituted with another nucleotide, wherein said DNA comprises the 4040th nucleotide of the nucleotide sequence of SEQ ID NO:
- 1;
- (b) a part or a whole of a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 2 or the sequence of SEQ ID NO:
- 2wherein the 6413th nucleotide has been substituted with another nucleotide, wherein said DNA comprises the 6413th nucleotide of the nucleotide sequence of SEQ ID NO:
- 2;
- (c) a part or a whole of a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 2 or the sequence of SEQ ID NO:
- 2 wherein the 14378th nucleotide has been substituted with another nucleotide, wherein said DNA comprises the 14378th nucleotide of the nucleotide sequence of SEQ ID NO:
- 2;
- and
- (d) a part or a whole of a DNA consisting of the nucleotide sequence of SEQ ID NO:
- 3 or the sequence of SEQ ID NO:
- 3 wherein the 6196th nucleotide has been substituted with another nucleotide, wherein said DNA comprises the 6196th nucleotide of the nucleotide sequence of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.