Liver transmembrane protein gene
OwnerYoumin Shu, Gilbert Jayinventors
Life of this patent
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Abstract
The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in liver and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such as hepatitis and carcinoma, especially relating to liver.
Claims19
A method of detecting human liver tissue in a sample, comprising:
- contacting said sample with a polynucleotide specific for human LAT-1 under conditions effective for said polynucleotide to hybridize specifically to human LAT-1, and
- detecting specific hybridization, whereby specific hybridization indicates that liver tissue is present in said sample.
A method of detecting human liver tissue in a sample comprising tissue, comprising:
- contacting said sample with a binding partner specific for human LAT-1 under conditions effective for said binding partner to bind specifically to human LAT-1, and
- detecting specific binding between said binding partner and said human LAT-1, whereby specific binding indicates that liver tissue is present in said sample.
A method of assessing liver function, comprising:
- detecting LAT-1 polypeptide, or fragments thereof, in a body fluid, whereby the level of LAT-1 polypeptide in said fluid is a measure of liver function.
A method of delivering an active agent to the liver, comprising:
- administering to a subject in need thereof, an effective amount of an active agent coupled to a binding partner specific for human LAT-1 polypeptide, wherein said binding partner is effective to deliver said active agent specifically to liver.
A method of treating a liver carcinoma in a host in need thereof, comprising
- administering to said host an amount of a human LAT-1 binding partner which is effective to treat said carcinoma.
Dependencies are inferred from the claim text.