Antisense modulation of jagged 2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorSusan M. Freier
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Jagged 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Jagged 2. Methods of using these compounds for modulation of Jagged 2 expression and for treatment of diseases associated with expression of Jagged 2 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding Jagged 2, wherein said compound specifically hybridizes with said nucleic acid molecule encoding Jagged 2 and inhibits the expression of Jagged 2.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding Jagged 2.
Dependencies are inferred from the claim text.