IL-1 receptor accessory protein
AssigneeImmunex Corporation
InventorsJohn E. Sims, Dirk E. Smith
Life of this patent
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Abstract
DNA encoding IL-1R AcP splice variant polypeptides, the polypeptides and methods for using the encoded polypeptides are disclosed.
Claims14
An isolated polynucleotide comprising SEQ ID NO:
- 1 wherein the nucleic acid at 1792 is A or C.
An isolated polynucleotide comprising a nucleic acid that encodes a polypeptide comprising SEQ ID NO:
- 2, wherein the amino acid 598 is Thr or Pro
An isolated polynucleotide comprising SEQ ID NO:
- 3.
An isolated polynucleotide comprising a nucleic acid that encodes a polypeptide comprising SEQ ID NO:
- 4.
An isolated polynucleotide comprising a molecule selected from the group consisting of:
- a) A polynucleotide that encodes a polypeptide comprising amino acid residues 384-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro;
- b) A polynucleotide that encodes a polypeptide comprising amino acid residues 379-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro;
- c) A polynucleotide that encodes a polypeptide comprising amino acid residues 389-685 of SEQ ID NO:
- 4;
- d) A polynucleotide that encodes a polypeptide comprising amino acid residues 379-685 of SEQ ID NO:
- 4;
- e) A polynucleotide that encodes a polypeptide comprising amino acid residues 449-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Pro or Thr;
- f) A polynucleotide that encodes a polypeptide comprising amino acid residues 449-685 of SEQ ID NO:
- 4
- g) A polynucleotide that encodes a fragment of a polypeptide described in (a-g), wherein the fragment interacts with a signal transduction factor;
- h) An isolated nucleic acid molecule that hybridizes to either strand of a denatured, double-stranded DNA comprising the polynucleotide of any one of a)-g) under conditions of moderate stringency in 50% formamide and 6×SSC, at 42° C. with washing conditions of 60° C., 0.5×SSC, 0.1% SDS;
- i) An isolated nucleic acid molecule that encodes a polypeptide that is at least 85% identical to the polypeptides described in a)-g), wherein the polypeptide interacts with a signal transduction factor;
- j) A polynucleotide that is degenerate to any of the polynucleotides of a)-i).
An expression vector comprising a polynucleotide that encodes a polypeptide comprising SEQ ID NO:
- 2, wherein the amino acid residue at 598 is Pro or Thr.
An expression vector comprising a polynucleotide that encodes a polypeptide comprising SEQ ID NO:
- 4.
A polypeptide selected from the group consisting of:
- a) A polypeptide comprising SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro;
- b) A polypeptide comprising SEQ ID NO:
- 4.
- c) A polypeptide comprising amino acids 449-685 of SEQ ID NO:
- 4;
- d) A polypeptide comprising amino acids 449-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro;
- e) A polypeptide comprising amino acids 384-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro;
- f) A polypeptide comprising amino acids 379-687 of SEQ ID NO:
- 2, wherein the amino acid at 598 is Thr or Pro
- g) A polypeptide comprising amino acids 379-685 of SEQ ID NO:
- 4;
- h) A polypeptide comprising amino acids 389-685 of SEQ ID NO:
- 4;
- i) A polypeptide comprising a fragment of a polypeptide of a)-h) wherein the fragment interacts with a signal transduction factor.
- j) A polypeptide that is at least 85% identical to a polypeptide of a)-g), wherein the polypeptide interacts with a signal transduction factor.
Dependencies are inferred from the claim text.