US 2003/0170630 A1Published application

Proteins and nucleic acids encoding same

OwnerJohn P. Alsobrook II, Velizar T. Tchernev +24inventors

InventorsJohn P. Alsobrook II, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Bryan D. Zerhusen, Meera Patturajan, Denise M. Lepley, Catherine E. Burgess, Richard A. Shimkets, William M. Grosse, Edward S. Szekeres JR., Corine A.M. Vernet, Li Li, Stacie J. Casman, Ference L. Boldog, Linda Gorman, Esha A. Gangolli, Elma R. Fernandes, Danier K. Rieger, Shlomit R. Edinger, Erik Gunther, Isabelle Millet, Paul Sciore, Karen Ellerman, John R. MacDougall, Glennda Smithson

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Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims49

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

6 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58;
(d) a variant of an amino acid sequence selected from the group consisting SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 26, 28, 40, 42, 44, 46, 48, 50, 52, 54, 56, and 58, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/032,189Filed 21 Dec 2001
Priority: 21 Dec 2000
Published: 11 Sep 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07K 14/47
From vertebrates: from mammals
A61K 38/00
Medicinal preparations containing peptides
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies
A61K 2039/53
Comprising whole cells, viruses or DNA/RNA: dNA vaccination

Family

Application60/257,495Us provisional application · filed 21 Dec 2000
Application60/258,171Us provisional application · filed 22 Dec 2000
Application60/269,940Us provisional application · filed 20 Feb 2001
Application60/274,192Us provisional application · filed 8 Mar 2001
Application60/277,826Us provisional application · filed 22 Mar 2001
Application60/279,840Us provisional application · filed 29 Mar 2001
Application60/282,981Us provisional application · filed 11 Apr 2001
Application60/283,656Us provisional application · filed 13 Apr 2001
Application60/309,247Us provisional application · filed 31 Jul 2001
Application60/311,754Us provisional application · filed 10 Aug 2001
Application60/313,331Us provisional application · filed 17 Aug 2001
US 2003/0170630 A1This patent

From the US filing history. Foreign family members aren’t listed.