Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer
AssigneeAgensys, Inc.
InventorsArthur B. Raitano, Mary Faris, Rene S. Hubert, Daniel Afar, Wangmao Ge, Pia M. Challita-Eid, Aya Jakobovits
Life of this patent
Estimating the term…
Abstract
A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers,. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
Claims72
A method for monitoring 85P1B3 gene products in a biological sample from a patient who has or who is suspected of having cancer, the method comprising:
- determining the status of 85P1B3 gene products expressed by cells in a tissue sample from an individual;
- comparing the status so determined to the status of 85P1B3 gene products in a corresponding normal sample;
- and,
- identifying the presence of aberrant 85P1B3 gene products in the sample relative to the normal sample.
A composition comprising:
- a substance that modulates the status of 85P1B3, or a molecule that is modulated by 85P1B3 whereby the status of a cell that expresses 85P1B3 is modulated.
A composition comprising a peptide region of at least 5 amino acids of FIG. 2 (SEQ ID NO.:
- ______) in any whole number increment up to 229 that includes an amino acid position selected from:
- an amino acid position having a value greater than 0.5 in the Hydrophilicity profile of FIG. 5, an amino acid position having a value less than 0.5 in the Hydropathicity profile of FIG. 6;
- an amino acid position having a value greater than 0.5 in the Percent Accessible Residues profile of FIG. 7;
- an amino acid position having a value greater than 0.5 in the Average Flexibility profile on FIG. 8;
- or an amino acid position having a value greater than 0.5 in the Beta-turn profile of FIG. 9.
A method of generating a mammalian immune response directed to 85P1B3, the method comprising:
- exposing cells of the mammal's immune system to an immunogenic portion of an 85P1B3-related protein or a nucleotide sequence that encodes said protein, whereby an immune response is generated to 85P1B3.
Dependencies are inferred from the claim text.