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US 2003/0170625 A1Published application
Detection of differential gene expressions
AssigneeMetagen Gesellschaft Fur Genomforschung MBH
InventorsAndre Rosenthal, Bernd Hinzmann, Reinhold Schaffer, Johannes Zuber, Oleg Tchernitsa, Martin Grips, Martin Hellriegel, Anne-Chantal Schmitz, Christine Sers
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Abstract
The invention relates to a process for detecting differential gene expressions and new nucleic acid sequences that can be obtained by this process.
Claims26
Nucleic acid, characterized in that it shows a differential expression in tumor cells and normal cells, comprising
- (a) one of the nucleic acid sequences shown in FIG. 11,
- (b) partial sequences thereof with a length of at least 50, preferably at least 100, and especially preferably at least 200 nucleotides,
- (c) a sequence that hybridizes with a sequence that consists of (a) and/or (b) under stringent conditions, and/or
- (d) a sequence that is complementary to a sequence that consists of (a), (b) and/or (c).
1 more element
Process for testing the influence of active substances on the gene expression, wherein
- an active substance is added to a cell line, RNA is isolated from the cell line, the RNA is labeled, then hybridized on an array, and then the gene expression profile of the cell line is obtained.
Dependencies are inferred from the claim text.