Treating asthma by preventing and/or accomodating for S-nitrosothiol breakdown
OwnerBenjamin Gaston, Jonathan S. Stamler +1inventors
InventorsBenjamin Gaston, Jonathan S. Stamler, Owen W. Griffith
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Abstract
Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown. The method reduces requirements for systemic corticosteroids for the treatment of severe asthma.
Claims30
A method for treating a patient with asthma to ameliorate symptoms thereof comprising administering to said patient (a) a therapeutically effective amount of an inhibitor of S-nitrosothiol breakdown except for aurothioglucose, gold sodium thiomalate and Auranofin or (b) therapeutically effective amounts of an NO donor and of an inhibitor of S-nitrosothiol breakdown, or (c) a therapeutically effective amount of an NO donor which is itself an S-nitrosothiol or which generates an S-nitrosothiol in vivo which is resistant to breakdown by catalysts which cause S-nitrosothiol breakdown.
A method for treating patients with mild or moderate asthma to inhibit progression to more severe asthma comprising administering to said patient (a) a therapeutically effective amount of an inhibitor of S-nitrosothiol breakdown except for aurothioglucose, gold sodium thiomalate and Auranofin or (b) therapeutically effective amounts of an NO donor and of an inhibitor of S-nitrosothiol breakdown or (c) a therapeutically effective amount of an NO donor which is itself an S-nitrosothiol or which generates S-nitrosothiol in vivo which is resistant to breakdown by catalysts which cause S-nitrosothiol breakdown.
Dependencies are inferred from the claim text.