Micro-particulate and nano-particulate polymeric delivery system
OwnerAles Prokopinventor
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Abstract
The present invention provides a method of making particles, e.g., nanoparticles that are stable in a physiological environment for at least a day. The nanoparticles comprise polyanionic polymers and polycations in a complex useful for drug delivery. The method comprises the step of capturing droplets comprising the polyanionic polymers in a solution comprising the polycations; or, alternatively, capturing droplets comprising the polycations in a solution comprising the polyanionic polymers. Also provided are methods of use for the particles.
Claims53
A method of making a nanoparticle that is stable in a physiological environment for at least a day, said nanoparticle comprising polyanionic polymers and polycations in a complex useful for drug delivery, said method comprising the step of:
- capturing droplets comprising said polyanionic polymers in a solution comprising said polycations;
- or, alternatively,
- capturing droplets comprising said polycations in a solution comprising said polyanionic polymers.
- wherein the complex structure forming the nanoparticle made thereby increases the stability thereof in a physiological environment
A method of increasing the entrapment efficiency of a nanoparticle comprising the steps:
- capturing droplets comprising polyanionic polymers and a salt in a solution comprising polycations, said polyanionic polymers and said polycations sufficient in number to form a ternary or quaternary polymeric nanoparticle structure;
- and
- forming said nanoparticle structure comprising a polyanionic/salt core and a polycationic/polyanionic complex corona with an excess positive charge on the nanoparticle periphery wherein the structure of the nanoparticle increases the stability thereof in a physiological environment thereby increasing entrapment efficiency.
A nanoparticle comprising:
- a core comprising polyanionic polymers and a salt;
- and
- a corona surrounding said core, said corona comprising a polycationic/polyanionic complex with an excess positive charge on the nanoparticle periphery, wherein said polyanionic polymers and said polycations are sufficient in number to form a ternary or quaternary polymeric nanoparticle structure.
A method of adjustment of biodegradability of polymeric mixtures, comprising the steps of:
- contacting an enzyme to a polysaccharide;
- degrading said polysaccharide at physiological conditions in vivo to degradation products.
A method of introducing an adjuvant to potentiate an immunogenic effect, comprising the steps of:
- administering said adjuvant as part of a droplet-forming polymeric mixture.
Dependencies are inferred from the claim text.