Tasteless, directly compressible, fast-dissolving complexes and pharmaceutical formulations thereof
OwnerHardeep Wadhwainventor
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Abstract
A tasteless, granular, directly compressible, stable, fast-dissolving complex of a bitter tasting basic drug, pharmaceutical formulations comprising the tasteless complex of the basic drug and dosage forms thereof are disclosed. The basic drug can be fexofenadine, and the complex of the basic drug can be a fexofenadine-carbomer complex. Processes for preparing, isolating and characterizing the tasteless complex of the bitter tasting basic drug and processes for producing the pharmaceutical formulations are also disclosed.
Claims69
A fexofenadine-carbomer complex comprising fexofenadine complexed with a carbomer.
A process for producing a complex of a basic drug comprising:
- removing an acid salt of the basic drug employing an alkali;
- and
- reacting the basic drug with an acidic polymer under conditions sufficient to form a complex of the basic drug with the acidic polymer.
A pharmaceutical formulation comprising a fexofenadine-carbomer complex and a pharmaceutically-acceptable excipient.
Dependencies are inferred from the claim text.