Inorganic-polymer complexes for the controlled release of compounds including medicinals
AssigneeRoyer Biomedical, Inc.
InventorGarfield P. Royer
Life of this patent
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Abstract
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
Claims21
(New) A method of treating infection in a mammal comprising administering to said mammal a solid composition comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- a) an antiinfective, b) calcium sulfate hemihydrate c) a matrix polymer, and/or d) a complexing agent.
(New) A method of treating cancer in a mammal comprising administering to said mammal a solid composition comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- a) an antineoplastic agent, b) calcium sulfate hemihydrate c) a matrix polymer, and/or d) a complexing agent.
(New) A method of vaccinating a mammal comprising administering to said mammal a solid composition comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- a) a vaccine, b) calcium sulfate hemihydrate c) a matrix polymer, and/or d) a complexing agent.
(New) A method of treating inflammation in a mammal comprising administering to said mammal a solid composition comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- a) an antiinflammatory, b) calcium sulfate hemihydrate c) a matrix polymer, and/or d) a complexing agent.
(New) A method of diagnosing disease in a mammal comprising administering a radiopaque matrix to said mammal.
(New) A method of scaffolding bone or filling a defect in bone comprising administering to said bone a solid composition consisting of:
- (a) an active agent;
- (b) calcium sulfate;
- and
- (c) a matrix polymer which slows the release of said active agent, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said matrix polymer and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- and
- (c) a matrix polymer which slows the release of said active agent, wherein said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said matrix polymer and said calcium sulfate hemihydrate, and wherein
- said composition is in the form of a bead, wafer, tablet, sphere.
(New) A solid composition for the controlled release of an active agent consisting of:
- (a) an active agent;
- (b) calcium sulfate;
- and
- (c) a matrix polymer which slows the release of said active agent, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said matrix polymer and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- and
- (c) polyethylene glycol, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said polyethylene glycol and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- and
- (c) dextran sulfate, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said dextran sulfate and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- (a) an active agent,
- (b) calcium sulfate hemihydrate,
- (c) a matrix polymer in an amount sufficient to slow the release of said active agent, and
- (d) water in an amount sufficient to form a solid matrix due to the hydration of said calcium sulfate hemihydrate, wherein
- said composition is in the form of a bead, wafer, tablet, sphere, granule or cylinder.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- (c) a matrix polymer which slows the release of said active agent, and
- (d) a salt of a fatty acid;
- wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said matrix polymer and said calcium sulfate hemihydrate, and wherein
- said composition is in the form of a bead, wafer, tablet, sphere.
(New) A solid composition for the controlled release of an active agent consisting of:
- (a) an active agent;
- (b) calcium sulfate;
- (c) a matrix polymer which slows the release of said active agent, and
- (d) a salt of a fatty acid, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said matrix polymer and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- (c) polyethylene glycol, and
- (d) a salt of a fatty acid, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said polyethylene glycol and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising:
- (a) an active agent;
- (b) calcium sulfate;
- (c) dextran sulfate, and
- (d) a salt of a fatty acid, wherein
- said composition is a solid matrix due to hydration of calcium sulfate hemihydrate in an aqueous mixture of said active agent, said dextran sulfate and said calcium sulfate hemihydrate.
(New) A solid composition for the controlled release of an active agent comprising an active agent which is dispersed throughout a solid matrix reaction product of an aqueous mixture comprised of:
- (a) an active agent,
- (b) calcium sulfate hemihydrate,
- (c) a matrix polymer in an amount sufficient to slow the release of said active agent,
- (d) water in an amount sufficient to form a solid matrix due to the hydration of said calcium sulfate hemihydrate, and
- (e) a salt of a fatty acid, wherein
- said composition is in the form of a bead, wafer, tablet, sphere, granule or cylinder.
Dependencies are inferred from the claim text.