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US 2003/0170304 A1Published application
Multiparticulate modified release composition
AssigneeElan Corporation, plc
InventorsJohn G. Devane, Paul Stark, Niall M. M. Fanning
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AssigneeElan Corporation, plc
InventorsJohn G. Devane, Paul Stark, Niall M. M. Fanning
Estimating the term…
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the immediate release component comprising a first population of active ingredient containing particles and the modified release component comprising a second population of active ingredient containing particles coated with a controlled release coating; wherein the combination of the immediate release and modified release components in operation deliver the active ingredient in a pulsed or a bimodal manner. The invention also relates to a solid oral dosage form containing such a multiparticulate modified release composition. The plasma profile achieved by the multiparticulate modified release composition is advantageous in reducing patient tolerance to the active ingredient and in increasing patient compliance by reducing dosage frequency.
A multiparticulate modified release composition containing at least one active ingredient and having a first component comprising a first population of active ingredient-containing particles and at least one subsequent component, each subsequent component comprising a subsequent population of active ingredient-containing particles, the active ingredient contained in the first and subsequent components being the same or different;
A method, wherein a multiparticulate modified release composition comprising:
Dependencies are inferred from the claim text.