Therapeutic methods for acute myeloid leukemia
OwnerRobert J. Lee, Manohar Ratnaminventors
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Abstract
The invention provides a method for treating leukemia in a patient. The method comprises administering to the patient a substance that increases expression of folate receptor β on leukemia cells in the patient, called a FR-β inducer, and administering a folate-conjugated therapeutic that targets the leukemia cells in the patient. The invention also comprises pharmaceutical compositions containing one or both of a FR-β inducer and a folate-conjugated therapeutic. The invention also provides a kit for use in treating leukemia in a patient, the kit comprising an FR-β inducer and a folate-conjugated therapeutic
Claims14
A method for treating leukemia in a patient, comprising:
- (a) administering at least one FR-β inducer to the patient to increase the levels of FR-β on the leukemia cells in the patient;
- and
- (b) administering a biologically effective amount of a folate-conjugated therapeutic to the patient.
A pharmaceutical composition comprising a FR-β inducer or a folate-conjugated therapeutic or both a FR-β inducer and a folate-conjugated therapeutic.
A kit for use in treating leukemia in a patient, the kit comprising one or more FR-β inducers and one or more folate-conjugated therapeutics.
Dependencies are inferred from the claim text.