Hydrogel composition for transdermal drug delivery
OwnerHo-Jin Kim, Hye-Jeong Yooninventors
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Abstract
The present invention relates to a hydrogel composition for transdermal drug delivery, more specifically to a hydrogel composition for transdermal drug delivery containing acrylate polymers like acrylic acid polymer, methacrylic acid polymer, alkyl acrylate polymer, alkyl methacrylate polymer or copolymers thereof as compatibilizers which enable both hydrophilic and lipophilic permeation enhancers to be applicable in the hydrogel composition in order to effectively control skin penetration of drugs.
Claims22
A transdermal drug delivery composition comprising a hydrophilic polymer base, a drug, a lipophilic permeation enhancer and a compatibilizer consisting essentially of an acrylate polymer which compatibilizes said lipophilic enhancer with said hydrophilic polymer base and which renders said composition thermodynamically stable.
A transdermal drug delivery composition comprising a hydrophilic polymer base comprising 2-30 wt. % of polyvinyl alcohol and 2-20 wt. % of polyvinyl pyrrolidone of said hydrophilic polymer base;
- a drug;
- a 0.1-65 wt. % of a lipophilic permeation enhancer based on the entire composition;
- and 0.1-10 wt. % of a compatibilizer based on the entire composition, said compatibilizer consisting essentially of an acrylate polymer which compatibilizes said lipophilic enhancer with said hydroplhilic polymer base and which renders said composition thermodynamically stable.
Dependencies are inferred from the claim text.