Compositions and methods for the therapy and diagnosis of lung cancer

A method for stimulating and/or expanding T cells specific for a tumor protein, comprising contacting T cells with at least one component selected from the group consisting of:

• (a) a polypeptide comprising an amino acid sequence set forth in any one of SEQ ID NOs:2005-2011, or an immunogenic fragment thereof;
• (b) a polypeptide consisting of an amino acid sequence set forth in any one of SEQ ID NOs:2005-2011 or an immunogenic fragment thereof;
• (c) a polypeptide comprising an amino acid sequence having at least 90% identity to a polypeptide of (a) or (b);
• (d) antigen-presenting cells pulsed with or expressing a polypeptide according to (a) (b), or (c);
• under conditions and for a time sufficient to permit the stimulation and/or expansion of T cells.

A method for stimulating an immune response in a patient, comprising administering to the patient an effective amount of a composition comprising at least one component selected from the group consisting of:

• (a) a polynucleotide comprising a sequence encoding a polypeptide set forth in any one of SEQ ID NOs:2005-2011, or an immunogenic fragment thereof;
• (b) a polynucleotide consisting of a sequence encoding a polypeptide set forth in any one of SEQ ID NOs:2005-2011 or an immunogenic fragment thereof;
• and
• (c) a polynucleotide comprising a sequence encoding a polypeptide sequence having at least 90% identity to a polypeptide of (a) or (b);
• (d) wherein the polynucleotide encodes a polypeptide capable of stimulating a human T-cell response.