Local delivery of long lasting therapeutic agents
OwnerAlan M. Ezrin, Peter G. Milner +2inventors
InventorsAlan M. Ezrin, Peter G. Milner, Dominique P. Bridon, Darren L. Holmes
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Abstract
Methods of and compositions for localized delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.
Claims52
A local delivery agent comprising a compound of the formula:
- X—Y-Z
- wherein X is selected from the group consisting of wound healing agents, antibiotics, anti-inflammatories, antioxidants, antiproliferatives, immunosuppressants, anti-infective and anti-cancer agents;
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith.
The composition of claim 5 wherein Z is N-hydroxysuccinimide.
A local delivery agent comprising a compound of the formula:
- X—Y-Z
- wherein X is selected from the group consisting of wound healing agents, anti-inflammatories, antiproliferatives, and chemotherapeutic agents;
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith.
A wound healing agent comprising a compound of the formula:
- X—Y-Z
- wherein X is a therapeutic agent that has wound healing properties;
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith.
A wound healing agent comprising a compound of the formula:
- X—Y-Z
- wherein X is an RGD containing peptide have wound healing properties;
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith.
A local delivery agent comprising a compound of the formula:
- X—Y-Z
- wherein X is an anti-restenosis, antiproliferative or an antiangiogenic agent wherein said agent is radioactive, wherein
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on a fixed blood component to form covalent bonds therewith.
A local delivery agent comprising a compound of the formula:
- X—Y-Z
- wherein X is an anti-restenosis, an antiproliferative or an antiangiogenic agent wherein said agent contains an RGD peptide
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith.
A local delivery agent comprising a compound of the formula:
- X—Y-Z
- wherein X is an anti-restenosis, an antiproliferative or an antiangiogenic agent wherein said agent includes a radioactive isotope, wherein
- Y is a linking group consisting of 0-30 atoms;
- and
- Z is a chemically reactive entity capable of reaction with a reactive functionality on a fixed blood component to form covalent bonds therewith.
A method of promoting wound healing at a wound site, comprising:
- applying a compound of the formula X—Y-Z wherein X is a wound healing agent, Y is a linking group between 0-30 atoms and Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith, wherein said compound is applied at or near said site to permit covalent bond formation of said compound to a reactive functionality near said site.
A method of treating a tumor, comprising:
- applying a compound of the formula X—Y-Z wherein X is an anti-cancer agent, Y is a linking group between 0-30 atoms and Z is a chemically reactive entity capable of reaction with a reactive functionality on fixed blood components to form covalent bonds therewith, wherein said compound is applied at or near said tumor to permit covalent bond formation of said compound to a reactive functionality at or near said tumor.
Dependencies are inferred from the claim text.