Humanized monoclonal antibodies that protect against shiga toxin induced disease

A humanized monoclonal antibody which binds Shiga toxin type 1, comprising a constant region and a variable region, wherein:

• said constant region is IgG1-kappa, and
• said variable region contains at least part of the sequence as set forth in FIG. 3 (SEQ ID NO:
• 19 and SEQ ID NO:
• 21).

A humanized monoclonal antibody which binds Shiga toxin type 1, comprising a constant region and a variable region, wherein:

• said constant region is IgG1-kappa, and said variable region contains at least part of the CDR sequences as set forth in FIG. 3, said CDR sequences located as follows:
• 7 Heavy Chain CDRs:
• CDR1-aa31-35 (SEQ ID NO:
• 19) CDR2-aa50-66 CDR3-aa99-111 Light Chain CDRs:
• CDR1-aa24-34 (SEQ ID NO:
• 21) CDR2-aa50-56 CDR3-aa89-97

A humanized monoclonal antibody which binds Shiga toxin type 2 and Shiga toxin type 2 variants, comprising a constant region and a variable region, wherein:

• said constant region is IgG1-kappa, and
• said variable region contains at least part of the CDR sequences as set forth in FIG. 6, said CDR sequences located follows:
• 8 Heavy Chain CDRs:
• CDR1-aa31-35 (SEQ ID NO:
• 44) CDR2-aa50-66 CDR3-aa99-108 Light Chain CDRs:
• CDR1-aa24-40 (SEQ ID NO:
• 42) CDR2-aa56-62 CDR3-aa95-103