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US 2003/0170247 A1Published application
Methods for detection and treatment of neural cancers
AssigneeThe Regents of the University of California
InventorLinda M. Liau
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AssigneeThe Regents of the University of California
InventorLinda M. Liau
Estimating the term…
The invention provides a method for inhibiting proliferation of neural cells. The neural cells can be tumor cells, glial cells, neuronal cells, and cells of the central or peripheral nervous systems. The method comprises contacting a neural cell with a molecule that disrupts the biological activity of a granulin molecule. In one embodiment, the molecule is an antibody directed against a granulin peptide. In other embodiments, the molecule is an antisense nucleotide directed against a granulin nucleic acid molecule, or a vaccine comprising a granulin peptide or a polynucleotide encoding a granulin peptide. The invention additionally provides methods for detecting and treating cancer in a neural tissue using granulin-related molecules. Also provided is a method for indenting differentially expressed gene products that are translated from mRNA species, using antibody-based screening of a cDNA expression library. This method, termed differential immuno-absorption (DIA), can be coupled to cDNA microarray hybridization and used in the identification of genes that play a role in the malignant progression of cancer.
A method for inhibiting proliferation of neural cells comprising contacting a neural cell with a molecule that disrupts the biological activity of a granulin molecule.
A method for treating cancer of the nervous system in a subject comprising administering to the subject a molecule that disrupts the biological activity of a granulin molecule.
A method for detecting cancer in a neural tissue comprising contacting the tissue with a molecule that recognizes and binds a granulin molecule.
A method for identifying a molecule that inhibits proliferation of neural cancer cells comprising:
A method for identifying proteins differentially expressed in a target tissue comprising:
A method of identifying a protein that is differentially expressed in a neural cancer comprising screening a first library of cells associated with neural cancer and a second library of non-tumor neural cells with a nucleic acid molecule encoding a candidate protein, wherein increased hybridization of the nucleic acid molecule with the first library relative to the second library is indicative of a protein that is differentially expressed in neural cancer.
Dependencies are inferred from the claim text.