Lipophilin complexes for use in cancer diagnosis and therapy
AssigneeCorixa Corporation
InventorsGary R. Fanger, Margarita Durham, Raymond L. Houghton, Davin C. Dillon, Darrick Carter, David H. Persing
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Abstract
Compositions and methods for the therapy and diagnosis of breast, ovarian and prostate cancer are disclosed. Compositions may comprise one or more lipophilin fusion proteins, which comprise at least two different lipophilin-like polypeptides linked by a peptide bond. Such compositions may be used for the prevention and treatment of breast, ovarian and prostate cancer. Diagnostic methods based on detecting the presence of lipophilin complexes, or antibodies thereto, in a patient are also provided.
Claims57
A fusion protein, comprising a first lipophilin-like polypeptide linked by a peptide bond to a second lipophilin-like polypeptide.
A fusion protein, comprising a lipophilin-like polypeptide linked by a peptide bond to a breast tumor antigen.
An isolated antibody, or antigen-binding fragment thereof, that specifically binds to lipophilin B.
An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a lipophilin complex.
An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a lipophilin B polypeptide wherein the lipophilin B polypeptide comprises an amino acid sequence of any one of SEQ ID NOs:68-76.
Dependencies are inferred from the claim text.