Treating Autoimmune Diseases with Humanized Anti-CD40L Antibody
AssigneeIDEC Pharmaceuticals Corporation
InventorsAmelia Black, Nabil Hanna, Eduardo A. Padlan, Roland A. Newman
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Abstract
The present invention is directed to humanized antibodies which bind human gp39 and their use as therapeutic agents. These humanized antibodies are especially useful for treatment of autoimmune diseases; and an immunosuppressant during transplantation of heterologous cells, tissues or organs, cell therapy, and gene therapy.
Claims34
A humanized antibody which is capable of competing with the murine 24-31 antibody for inhibiting CD40 binding to gp39.
A humanized antibody derived from murine monoclonal antibody 24-31.
A humanized antibody derived from murine monoclonal antibody 24-31 which retains at least about one-third the gp39 antigen binding affinity of the murine 24-31 antibody.
A humanized antibody derived from murine monoclonal antibody 24-31 which retains the half-maximal potency in in vitro functional activity in a B cell assay at a concentration of not more than three times the concentration of the parent murine 24-31 antibody.
A pharmaceutical composition which contains a humanized antibody derived from murine monoclonal antibody 24-31.
A method of suppressing humoral and/or cellular immune responses against cells or vectors administered during cell or gene therapy comprising further administering prior, during or after gene therapy an amount of a humanized antibody derived from murine antibody 24-31 sufficient to suppress humoral and/or cellular immune responses against the cell or vector used during cell or gene therapy.
An improved method of treatment which involves the transplantation of cells, tissues or organs of the same or different species into a subject in need of such treatment, wherein the improvement comprises administering a humanized anti-human gp39 antibody derived from murine antibody 24-31;
- prior, during or after transplantation;
- in an amount sufficient to suppress immune responses against said transplanted cell, tissue or organ or to suppress immune responses elicited by the transplanted cell, tissue or organ against the host.
Dependencies are inferred from the claim text.