Agents that specifically block CD28-mediated signaling and uses therefor
AssigneeGenetics Institute, Inc.
InventorsRichard M. O'Hara JR., Ann Marie Nagelin
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Abstract
The instant invention provides compositions and methods for downmodulation of immune responses, e.g., autoimmune responses. For example, methods of downmodulating an immune response using agents that specifically block CD28-mediated signaling are provided. The subject methods are useful for both prophylactic and therapeutic downmodulation of immune responses.
Claims24
A method of therapeutically downmodulating an autoimmune response in a subject comprising administering an antigen binding portion of an anti-CD28 antibody that blocks signaling via CD28 to the subject such that an autoimmune response in the subject is downmodulated.
A method of therapeutically downmodulating an autoimmune response in a subject comprising administering a small molecule that specifically blocks signaling via CD28 to the subject such that an autoimmune response in the subject is downmodulated.
A method of therapeutically downmodulating an ongoing autoimmune response in a subject comprising administering an antigen binding portion of an anti-CD28 antibody that blocks signaling via CD28 to the subject such that an ongoing autoimmune response in the subject is downmodulated.
A method of therapeutically downmodulating an ongoing autoimmune response in a subject comprising administering a small molecule that specifically blocks signaling via CD28 to the subject such that an ongoing autoimmune response in the subject is downmodulated.
A method of prophylactically downmodulating an autoimmune response in a subject comprising administering an antigen binding portion of an anti-CD28 antibody that blocks signaling via CD28 to the subject such that an autoimmune response in the subject is downmodulated or delayed in its onset.
A method of prophylactically downmodulating an autoimmune response in a subject comprising administering a small molecule that specifically blocks signaling via CD28 to the subject such that an autoimmune response in the subject is downmodulated or delayed in its onset.
Dependencies are inferred from the claim text.