Compositions and methods for assembly and stabilization of antibody Fv fragments via antiparallel heterogeneous coiled-coil peptide regions and uses thereof
OwnerNigel Robert Caterer, Lars Otto Uttenthal +1inventors
InventorsNigel Robert Caterer, Lars Otto Uttenthal, Rasmus Wendelbo Nielsen
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Abstract
Compositions and methods using antiparallel heterogeneous α-helical coiled-coil (AHEC) regions for the linkage and stabilization of antibody Fv domains are provided.
Claims15
A composition comprising a pair of antibody Fv fragments linked and stabilized by antiparallel heterogeneous α-helical coiled-coil (AHEC) peptides.
A method for stabilizing and assembling a pair of antibody Fv fragments into a multimeric complex comprising linking the pair of antibody Fv fragment via their C termini with antiparallel heterogeneous α-helical coiled-coil (AHEC) peptides.
Dependencies are inferred from the claim text.