Compositions and methods for the treatment of tumor

An article of manufacture, comprising:

• a container;
• a label on the container;
• and
• a composition comprising an active agent contained within the container, wherein the composition is effective for inhibiting the growth of tumor cells and wherein the label on the container indicates that the composition is effective for treating conditions characterized by overexpression of a PRO197, PRO207, PRO226, PRO232, PRO243, PRO256, PRO269, PRO274, PRO304, PRO339, PRO1558, PRO779, PRO1185, PRO1245, PRO1759, PRO5775, PRO7133,PRO7168, PRO5725, PRO202, PRO206, PRO264, PRO313, PRO342, PRO542, PRO773, PRO861, PRO1216, PRO1686, PRO1800, PRO3562, PRO9850, PRO539, PRO4316 or PRO4980 polypeptide in said tumor cells as compared to in normal cells of the same tissue type.

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence that encodes an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO. 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) and FIG. 70 (SEQ ID NO:
• 70).

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the nucleotide sequence shown in FIG. 1 (SEQ ID NO:

• 1), FIG. 3 (SEQ ID NO:
• 3), FIG. 5 (SEQ ID NO:
• 5), FIG. 7 (SEQ ID NO:
• 7), FIG. 9 (SEQ ID NO:
• 9), FIG. 11 (SEQ ID NO:
• 11), FIG. 13 (SEQ ID NO:
• 13), FIG. 15 (SEQ ID NO:
• 15), FIG. 17 (SEQ ID NO:
• 17), FIG. 19 (SEQ ID NO:
• 19), FIG. 21 (SEQ ID NO:
• 21), FIG. 23 (SEQ ID NO:
• 23), FIG. 25 (SEQ ID NO:
• 25), FIG. 27 (SEQ ID NO:
• 27), FIG. 29 (SEQ ID NO:
• 29), FIG. 31 (SEQ ID NO:
• 31), FIG. 33 (SEQ ID NO:
• 33), FIG. 35 (SEQ ID NO:
• 35), FIG. 37 (SEQ ID NO:
• 37), FIG. 39 (SEQ ID NO:
• 39), FIG. 41 (SEQ ID NO:
• 41), FIG. 43 (SEQ ID NO:
• 43), FIG. 45 (SEQ ID NO:
• 45), FIG. 47 (SEQ ID NO:
• 47), FIG. 49 (SEQ ID NO:
• 49), FIG. 51 (SEQ ID NO:
• 51), FIG. 53 (SEQ ID NO:
• 53), FIG. 55 (SEQ ID NO:
• 55), FIG. 57 (SEQ ID NO:
• 57), FIG. 59 (SEQ ID NO:
• 59), FIG. 61 (SEQ ID NO:
• 61), FIG. 63 (SEQ ID NO:
• 63), FIG. 65 (SEQ ID NO:
• 65), FIG. 67 (SEQ ID NO:
• 67) and FIG. 69 (SEQ ID NO:
• 69).

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence selected from the group consisting of the full-length coding sequence of the nucleotide sequence shown in FIG. 1 (SEQ ID NO:

• 1), FIG. 3 (SEQ ID NO:
• 3), FIG. 5 (SEQ ID NO:
• 5), FIG. 7 (SEQ ID NO:
• 7), FIG. 9 (SEQ ID NO:
• 9), FIG. 11 (SEQ ID NO:
• 11), FIG. 13 (SEQ ID NO:
• 13), FIG. 15 (SEQ ID NO:
• 15), FIG. 17 (SEQ ID NO:
• 17), FIG. 19 (SEQ ID NO:
• 19), FIG. 21 (SEQ ID NO:
• 21), FIG. 23 (SEQ ID NO:
• 23), FIG. 25 (SEQ ID NO:
• 25), FIG. 27 (SEQ ID NO:
• 27), FIG. 29 (SEQ ID NO:
• 29), FIG. 31 (SEQ ID NO:
• 31), FIG. 33 (SEQ ID NO:
• 33), FIG. 35 (SEQ ID NO:
• 35), FIG. 37 (SEQ ID NO:
• 37), FIG. 39 (SEQ ID NO:
• 39), FIG. 41 (SEQ ID NO:
• 41), FIG. 43 (SEQ ID NO:
• 43), FIG. 45 (SEQ ID NO:
• 45), FIG. 47 (SEQ ID NO:
• 47), FIG. 49 (SEQ ID NO:
• 49), FIG. 51 (SEQ ID NO:
• 51), FIG. 53 (SEQ ID NO:
• 53), FIG. 55 (SEQ ID NO:
• 55), FIG. 57 (SEQ ID NO:
• 57), FIG. 59 (SEQ ID NO:
• 59), FIG. 61 (SEQ ID NO:
• 61), FIG. 63 (SEQ ID NO:
• 63), FIG. 65 (SEQ ID NO:
• 65), FIG. 67 (SEQ ID NO:
• 67) and FIG. 69 (SEQ ID NO:
• 69).

An isolated polypeptide having at least 80% amino acid sequence identity to an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) and FIG. 70 (SEQ ID NO:
• 70).

An isolated polypeptide scoring at least 80% positives when compared to an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) and FIG. 70 (SEQ ID NO:
• 70).

Isolated nucleic acid having at least 80% nucleic acid sequence identity to:

• (a) a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) or FIG. 70 (SEQ ID NO:
• 70), lacking its associated signal peptide;
• (b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) or FIG. 70 (SEQ ID NO:
• 70), with its associated signal peptide;
• or
• (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) or FIG. 70 (SEQ ID NO:
• 70), lacking its associated signal peptide.

An isolated polypeptide having at least 80% amino acid sequence identity to:

• (a) the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) or FIG. 70 (SEQ ID NO:
• 70), lacking its associated signal peptide;
• (b) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO:
• 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO:
• 68) or FIG. 70 (SEQ ID NO:
• 70), with its associated signal peptide;
• or
• (c) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
• 2), FIG. 4 (SEQ ID NO:
• 4), FIG. 6 (SEQ ID NO:
• 6), FIG. 8 (SEQ ID NO:
• 8), FIG. 10 (SEQ ID NO:
• 10), FIG. 12 (SEQ ID NO:
• 12), FIG. 14 (SEQ ID NO:
• 14), FIG. 16 (SEQ ID NO:
• 16), FIG. 18 (SEQ ID NO:
• 18), FIG. 20 (SEQ ID NO:
• 20), FIG. 22 (SEQ ID NO:
• 22), FIG. 24 (SEQ ID NO:
• 24), FIG. 26 (SEQ ID NO:
• 26), FIG. 28 (SEQ ID NO:
• 28), FIG. 30 (SEQ ID NO:
• 30), FIG. 32 (SEQ ID NO:
• 32), FIG. 34 (SEQ ID NO:
• 34), FIG. 36 (SEQ ID NO:
• 36), FIG. 38 (SEQ ID NO:
• 38), FIG. 40 (SEQ ID NO:
• 40), FIG. 42 (SEQ ID NO:
• 42, FIG. 44 (SEQ ID NO:
• 44), FIG. 46 (SEQ ID NO:
• 46), FIG. 48 (SEQ ID NO:
• 48), FIG. 50 (SEQ ID NO:
• 50), FIG. 52 (SEQ ID NO. 52), FIG. 54 (SEQ ID NO:
• 54), FIG. 56 (SEQ ID NO:
• 56) FIG. 58 (SEQ ID NO:
• 58), FIG. 60 (SEQ ID NO:
• 60), FIG. 62 (SEQ ID NO:
• 62), FIG. 64 (SEQ ID NO:
• 64), FIG. 66 (SEQ ID NO:
• 66), FIG. 68 (SEQ ID NO.68) or FIG. 70 (SEQ ID NO:
• 70), lacking its associated signal peptide.