Disease associated protein kinases
AssigneeIncyte Pharmaceuticals, Inc.
InventorsOlga Bandman, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Preeti Lal, Surya K. Goli, Purvi Shah
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Abstract
The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
Claims21
An isolated polynucleotide, or the complement thereof, encoding a polypeptide selected from the group consisting of:
- a) SEQ ID NOs:2, 4, 5, 6, or 7, and
- b) a naturally-occurring amino acid sequence having at least 90% sequence identity over the complete sequence of SEQ ID NOs:1, 2, 4, or 7, and which retains protein kinase activity.
An isolated polynucleotide sequence selected from SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, and SEQ ID NO:14, or the complement thereof.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) SEQ ID NOs:1, 2, 4, 5, 6, or 7, and
- b) a naturally-occurring amino acid sequence having at least 90% sequence identity over the complete sequence of SEQ ID NOs:1,2, 4, or 7, and which retains protein kinase activity.
Dependencies are inferred from the claim text.