Bifidobacterium in the treatment of inflammatory disease
AssigneeEnterprise Ireland (Trading as Bioresearch Ireland and National University of Ireland, Cork.
InventorsJohn Kevin Collins, Gerald Christopher O'Sullivan, Liam O'Mahony, Fergus Shanahan
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Abstract
A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
Claims54
A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract which is significantly immunomodulatory following oral consumption in humans.
A strain of Bifidobacterium longum infantis isolated from resected and washed human gastrointestinal tract which is significantly immunomodulatory following oral consumption in humans.
A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract which is capable of combating the effects of inflammatory bowel disease, said capability being maintained in the presence of physiological concentrations of human bile and human gastric juice.
A strain of Bifidobacterium as claimed in any preceding claim, which has inhibitory activity against a broad range of Gram positive and Gram negative bacteria.
A strain of Bifidobacterium as claimed in preceding claim, wherein the strain exhibits a broad-spectrum of activity against bacteria including Staphylococcus, Pseudomonas, Coliform and Bacillus species.
A strain of Bifidobacterium longum infantis UCC35624.
A strain of Bifidobacterium longum infantis UCC35624 or mutant or variant thereof isolated from resected and washed human gastrointestinal tract which is significantly immunomodulatory following oral consumption in humans.
Dependencies are inferred from the claim text.