Methods and compositions for enhancing cognitive function using morphogenic proteins
OwnerMarc F. Charetteinventor
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Abstract
Disclosed are methods and compositions for protecting cognitive function in a mammal, particularly a human, subject to brain tissue damage, by administering a morphogen or a nucleic acid encoding a morphogen to the mammal. The methods and compositions can be used to reduce memory dysfunction and/or to provide a neuroprotective effect in subjects at risk of memory dysfunction resulting from mechanical or chemical trauma, neuropathies, neurodegenerative diseases, or oxygen or glucose deprivation.
Claims25
A method for protecting cognitive function in a mammal comprising administering to the mammal a morphogen or nucleic acid encoding the morphogen.
A method for reducing memory dysfunction in a mammal, the method comprising the step of administering to the mammal a morphogen or a nucleic acid encoding the morphogen.
A method for treating dementia in a mammal, comprising the step of administering to the mammal a morphogen or a nucleic acid encoding the morphogen.
A method for treating a symptom associated with hippocampal tissue damage in a mammal, comprising the step of administering to the mammal a morphogen or a nucleic acid encoding the morphogen.
The method of claim 12 wherein morphogen is administered intravenously.
A composition for protecting cognitive function and/or reducing cognitive dysfunction in a mammal, the composition comprising a morphogen in an amount sufficient to protect cognitive function and/or reduce cognitive dysfunction in said mammal.
A composition for protecting cognitive function and/or reducing cognitive dysfunction in a mammal, the composition comprising cultured cells competent to express a morphogen in an amount sufficient to protect cognitive function and/or reduce cognitive dysfunction in said mammal.
A composition for protecting cognitive function and/or reducing cognitive dysfunction in a mammal, the composition comprising a recombinant nucleic acid comprising a DNA sequence encoding a morphogen and a promoter in operative association therewith, in an
Dependencies are inferred from the claim text.