Stable aqua formulation of interferon, the preparation method and the uses thereof
OwnerLei Zhanginventor
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Abstract
The present invention relates to a stable interferon alpha aqueous solution formulation that may be preservative or human blood extracted ingredient free, which comprises of the following components: a. interferon alpha; b. a buffer system to maintain pH 4.5-9.0; c. a stabilizing agent; d. a nonionic surfactant; e. an osmotic pressure regulator; the preparation method and the uses in the treatment of viral, tumorous and immune diseases thereof.
Claims28
A stable interferon aqueous solution formulation that may be preservative or human blood extracted ingredient free, which comprises the following components:
- a. interferon alpha;
- b. a buffer system to maintain pH 4.5-9.0;
- c. a stabilizing agent;
- d. a nonionic surfactant;
- e. an osmotic pressure regulator;
- f. injection water:
A stable interferon aqueous solution formulation that may be preservative or human blood extracted ingredient free, which comprises the following components:
- a. 100,000-100,000,000 IU/ml interferon alpha-2b;
- b. a buffer system of citric acid and disodium hydrogen phosphate to maintain pH of 4.5-9.0;
- c. 5-60 mg/ml of hydroxyethyl starch;
- d. 0.02-0.2 ml/100 ml of polyoxyethylene sorbitan monooleate;
- e. 1-10 mg/ml of sodium chloride and 10 mgl/ml of mannitol.
A use of the combination of interferon alpha, buffer system to maintain pH 4.5-9.0, stabilizing agent, nonionic surfactants, isotonicity agent in preparing the stable interferon aqueous solution formulation that may be preservative and human serum albumin free.
Dependencies are inferred from the claim text.