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US 2003/0170202 A1Published application
Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
AssigneeRutgers, The State University of New Jersey
InventorKathryn E. Uhrich
Life of this patent
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Abstract
Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
Claims36
A polymer having a structure selected from the group consisting of:
- R(—O—R1), and R(—NH—R1)x
- wherein R(—O—)x is a polyol moiety and R(—NH)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure:
- 7
- wherein
- 8
- is a divalent amino acid moiety with R2 being a covalent bond or having from 1 to 8 carbon atoms, and y and z are between 0 and 10, inclusive, provided that y and z are not both 0;
- wherein
- 9
- is a divalent dicarboxylic acid moiety in which R3 is an alkylene or cycloalkylene group containing from 1 to about 15 carbon atoms, substituted with a total of from 1 to about 10 hydroxyl groups, with at least a portion of the hydroxyl groups being acylated with from 3 to about 24 carbon atom carboxylic acids;
- and
- wherein R4 is a poly(alkylene oxide) having the structure:
- R5—(R6—O—)a—R6-Q-
- with R5 being selected from the group consisting of 1 to 40 carbon atom alkyl groups, —OH, —OR7, —NH2, —NHR7, —NHR7R8, —C—OH, —C—OR7, —C—O—C—R7, —C—NH2, —C—NHR7 and —C—NR7R8;
- R6, R7 and R8 being independently selected from the group consisting of 2 to 40 carbon atom, straight-chain or branched alkylene groups;
- Q being a divalent linkage moiety;
- and
- a being between 2 and 110, inclusive;
- with the proviso that when y is 0 and R is a 1,1,1-tris(hydroxyphenyl)ethane moiety, the divalent dicarboxylic acid moiety is not an acylated mucic acid moiety.
15 more elements
A hydrophobic molecule encapsulated in a polymer, said polymer having a structure selected from the group consisting of:
- R(—O—R1)x and R(—NH—R1)x
- wherein R(—O—)x is a polyol moiety and R(—NH—)x is a polyamine moiety, with x being between 2 and 10, inclusive, and each R1 independently has the structure:
- 10
- wherein
- 11
- is a divalent amino acid moiety with R2 being a covalent bond or having from 1 to 8 carbon atoms, and y and z are between 0 and 10, inclusive, provided that y and z are not both 0;
- wherein
- 12
- is a divalent dicarboxylic acid moiety in which R3 is an alkylene or cycloalkylene group containing from 1 to about 15 carbon atoms, substituted with a total of from 1 to about hydroxyl groups, with at least a portion of the hydroxyl groups being acylated with from 3 to about 24 carbon atom carboxylic acids;
- and
- wherein R4 is a poly(alkylene oxide) having the structure:
- R5—(—R6—O—)a—R6-Q
- with R5 being selected from the group consisting of 1 to 40 carbon atom alkyl groups, —OH, —OR7, —NH2, —NHR7, —NHR7R8, —C—OH, —C—OR7, —C—O—C—R7, —C—NH2, —C—NHR7, and —C—NR7R8;
- R6, R7 and R8 being independently selected from the group consisting of 2 to 40 carbon atom, straight-chain or branched alkylene groups;
- Q being a divalent linkage moiety;
- and
- a being between 2 and 110, inclusive;
- with the proviso that when y is 0 and R is a 1,1,1-tris (hydroxyphenyl)ethane moiety, the divalent dicarboxylic acid moiety is not a mucic acid moiety acylated with carboxylic acids having less than 6 carbon atoms.
15 more elements
Dependencies are inferred from the claim text.