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US 2003/0170195 A1Published application
Compositions and methods for drug delivery
AssigneeNoven Pharmaceuticals, Inc.
InventorsDavid Houze, Juan Mantelle, David Kanios
Life of this patent
Estimating the term…
Abstract
A dermal composition for administration of an amphetamine drug comprising a blend of two or more acrylic-based polymers having differing functionalities so as to modulate the drug solubility in the polymer matrix and the delivery rate of the drug, and methods therefor.
Claims31
A dermal composition comprising a blend of:
- (a) a polymer composition of two or more polymers which includes:
- (i) a first acrylic-based polymer having a first functionality and solubility parameter;
- and
- (ii) a second acrylic-based polymer having a second functionality and solubility parameter, wherein the first and second functionalities differ in the amount and type of functional groups to provide an acrylic-based polymer combination having a net functionality proportional to the ratio of the first and second acrylic-based polymers used, and are present in proportions to provide a net solubility parameter;
- and
- (b) a therapeutically effective amount of one or more drugs incorporated into the polymer composition wherein the one or more drugs are selected from the group consisting of methamphetamine, amphetamine, d-amphetamine, and phentermine.
3 more elements
A method of producing a dermal composition, comprising the steps of:
- (1) producing a blend of:
- (a) a polymer composition of two or more polymers which includes:
- (i) a first acrylic-based polymer having a first functionality and solubility parameter;
- and
- (ii) a second acrylic-based polymer having a second functionality and solubility parameter, wherein the first and second functionalities differ in the amount and type of functional groups to provide an acrylic-based polymer combination having a net functionality proportional to the ratio of the first and second acrylic-based polymers used, and are blended in proportions to provide a net solubility parameter;
- and
- (b) a therapeutically effective amount of one or more drugs selected from the group consisting of amphetamine, methamphetamine, d-amphetamine, and phentermine;
- (2) forming the blend into a polymer matrix;
- and
- (3) drying the polymer matrix to remove the solvent system to form the dermal composition.
7 more elements
A method of controlling the flux of a drug from a dermal drug delivery composition, comprising the steps of:
- (a) selecting at least two polymer polymers which includes:
- (i) a first acrylic-based polymer having a first functionality and solubility parameter;
- and
- (ii) a second acrylic-based polymer having a second functionality and solubility parameter, wherein said first and second functionalities differ in the amount and type of functional groups to provide a polymer combination having a net solubility of one or more drugs within the composition proportional to the ratio of the first and second acrylic-based polymers used;
- (b) combining the at least two acrylic-based polymers with a therapeutically effective amount of one or more drugs selected from the group consisting of amphetamine, methamphetamine, d-amphetamine, and phentermine to form the dermal drug delivery composition, wherein the net solubility is different than the flux of a composition produced solely from said first or second acrylic-based polymers alone.
2 more elements
Dependencies are inferred from the claim text.