Contrast agents
OwnerJo Klaveness, Helge Tolleshaug +2inventors
InventorsJo Klaveness, Helge Tolleshaug, Alan Cuthbertson, Mari Ann Kulseth
Life of this patent
Estimating the term…
Abstract
This invention relates to contrast agents and the use of these contrast agents for diagnosis of diseases in humans and animals based on mapping of metabolic activity. The contrast agents can be used to identify tissue or cells with metabolic activity or enzymatic activity deviating from the normal. A contrast agent substrate changes pharmacodynamic and/or pharmacokinetic properties upon a chemical modification from a contrast agent substrate to a contrast agent product in a specific enzymatic transformation, thereby detecting areas of disease upon a deviation in the enzyme activity from the normal.
Claims20
A contrast agent substrate susceptible of changing pharmacodynamic and/or pharmacokinetic properties upon the influence of enzymatic activity.
A method for detection of abnormal enzymatic activity characterized in that a contrast agent substrate is administered to a human or animal body and a contrast agent signal is detected as a result of the contrast agent changing pharmacodynamic and/or pharmacokinetic properties upon the influence of enzymatic activity.
Dependencies are inferred from the claim text.