Animal model of atrial fibrillation and screening and therapeutic methods relating thereto
OwnerDan M. Roden, Sabina Kupershmidtinventors
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Abstract
An animal model of atrial fibrillation and a method of identifying an animal exhibiting an atrial fibrillation phenotype. The method includes providing an animal having a minK (−/−) genotype; recording electrocardiograms from the animal over an extended time period; and identifying an atrial fibrillation pattern in the electrocardiograms to thereby identify the animal as exhibiting an atrial fibrillation phenotype. A method of screening candidate substances for activity in the treatment of atrial fibrillation using an animal model is also disclosed, as is a method of treating atrial fibrillation using a candidate compound identified as having activity in the treatment of atrial fibrillation.
Claims34
A method for identifying an animal exhibiting an atrial fibrillation phenotype, the method comprising:
- (a) providing an animal having a minK (−/−) genotype;
- (b) recording electrocardiograms from the animal provided in step (a) over an extended time period;
- and
- (c) identifying an atrial fibrillation pattern in the electrocardiograms to thereby identify the animal as exhibiting an atrial fibrillation phenotype.
A non-human animal having an minK (−/−) genotype and an atrial fibrillation phenotype.
A method for screening candidate substances for an ability to modulate atrial fibrillation, the method comprising:
- (a) providing an animal model having an atrial fibrillation phenotype and a minK (−/−) genotype;
- (b) administering a candidate compound to the animal model;
- and
- (c) measuring atrial fibrillation in the animal model to thereby determine the ability of the candidate substance to modulate atrial fibrillation.
A method of screening candidate substances for an ability to modulate atrial fibrillation, the method comprising:
- (a) establishing replicate test and control animal models having an atrial fibrillation phenotype and a minK (−/−) genotype;
- (b) administering a candidate substance to the test animal model but not to the control animal model;
- (c) measuring cardiac rhythm in the test and the control animal models;
- and
- (d) determining that the candidate substance modulates atrial fibrillation based upon a comparison of the cardiac rhythms measured in the test and control animal models.
A method of modulating atrial fibrillation in a vertebrate, the method comprising administering to a vertebrate in need thereof an effective amount of a substance capable of modulating atrial fibrillation in the vertebrate, whereby modulation of atrial fibrillation is accomplished.
Dependencies are inferred from the claim text.