Loading patent…
AssigneeKanto Kagaku Kabushiki Kaisha
InventorsKunihiko Tsutsumi, Kunihiko Murata, Takeshi Ota, Takao Ikariya
Estimating the term…
The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand. In a preferred embodiment, the invention provides an optically active ruthenium complex represented by the general formula (1) 1 wherein X and Y, which can be identical to or different from each other, represent a hydrogen atom or an anion group, R1 and R2, which can be identical to or different from each other, represent a chain or cyclic hydrocarbon group of carbon number 1 to 20, which can be substituted, R3 and R4, which can be identical to or different from each other, represent a hydrogen atom or a hydrocarbon group of carbon number 1 to 3, and R5, R6, R7 and R8, which can be identical to or different from one another, represent a hydrocarbon group of carbon number 1 to 30, which can be substituted, with the proviso that when X and Y are bromine, R1 and R2 are a methyl group, and when R3 and R4 are a hydrogen atom, at least one of R5, R6, R7 and R8is not a phenyl group.
An optically active ruthenium complex represented by the general formula (1)
A ruthenium complex represented by the general formula (2)
A process for preparing an alcoholic compound, wherein said process comprises a step of preparing the alcoholic compound by reducing a carbonyl compound with the reaction of hydrogen or a compound donating hydrogen in the presence of an optically active ruthenium complex represented by the general formula (1)
A process for preparing an alcoholic compound, wherein said process comprises a step for preparing the alcoholic compound by reducing a carbonyl compound with the reaction of hydrogen or a compound donating hydrogen in the presence of an ruthenium complex represented by the general formula (2)
A process for preparing an optically active ruthenium complex represented by the general formula (1)
A process for preparing a ruthenium complex represented by the general formula (2)
Dependencies are inferred from the claim text.