Intermediates for use in the preparation of vitamin e
AssigneeAdisseo France S.A.S.
InventorsJean-Erick Ancel, Pierre Meilland
Life of this patent
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Abstract
Novel intermediate compounds which can be used in the preparation of phytone and Vitamin E and a process for the preparation thereof. A process for the preparation of phytone and Vitamin E from these compounds is also claimed.
Claims16
A process for the preparation of a compound of general formula (I)
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- wherein A is a C1 to C20 hydrocarbon, Y and Z independently represent a C1 to C20 hydrocarbon which may contain an oxygenated functional group, B represents OR1 or NHR1 where R1 is hydrogen or a C1 to C6 hydrocarbon, which process comprises reacting, in the presence of a Lewis acid catalyst, a compound of the general formula (II)
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- wherein Y and Z are as herein before defined with a compound of the general formula (III) or a compound of general formula (IV)
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- wherein a, and b are as hereinbefore defined and r is hydrogen or a C1 to C6 hydrocarbon.
A process as claimed in any one of the preceding claims in which compounds of formula (III) are 3 methyl butanal;
- imines of 3-methyl butanal;
- 3,6-dimethyl octanal;
- imines of 3,6-dimethyl octanal;
- citral and imines of citral
A process as claimed in any one of the preceding claims in which compounds of formula (V) are acetals of citral;
- acetals of 3-methyl butanal or acetals of 3,6-dimethyl octanal,
A process as claimed in any one of the preceding claims in which the Lewis acid is of general formula M(L) where M represents aluminium, iron, magnesium, scandium, ytterium, zinc, titanium, silicium and bismuth;
- L represents a halide, CF3SO3, (CF3SO2)2N, ClO4 or a C1 to C4 alkyl, and n corresponds to the electronic valency of M and suitably is from 1 to 4 or general formula A-H wherein A represents CF3SO3 or (CF3SO2)2N.
A process as claimed in any one of the preceding claims carried out in the presence of a base selected from aromatic amines, aliphatic amines and carbonate salts of Group I or II of the Periodic Table.
A process as claimed in any one of the preceding claims carried out in the presence of an organic solvent selected from chlorinated solvents, organic solvents, ether solvents, nitrile solvents and nitro solvents.
A process as claimed in any one of the preceding claims carried out at a temperature of from −80 to +150° C. and under atmospheric pressure.
Novel compounds characterised by the following structures
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Dependencies are inferred from the claim text.