Process for the preparation of indole derivatives and intermediates of the process
AssigneeCiba Specialty Chemicals Corporation
InventorsAnnemarie Wolleb, Heinz Wolleb
Life of this patent
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Abstract
A process for the preparation of compounds of formula (1), wherein R1 is C1-C6alkyl and X is hydrogen, a hydrocarbon radical or a cation, wherein a compound of formula (2), wherein R1 is as defined above and R2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula (3) is reacted with a compound that introduces the radical of formula —CH2—COOR3, wherein R3 has the meanings given above for R2, and the resulting compound of formula (4) is reduced and optionally hydrolysed.
Claims28
A process for the preparation of a compound of formula
- 35
- wherein R1 is C1-C6alkyl and
- X is hydrogen, a hydrocarbon radical or a cation,
- wherein a compound of formula
- 36
- wherein R1 is as defined above and R2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula
- 37
- wherein R1 and R2 are as defined above, is reacted with a compound that introduces the radical of formula —CH2—COOR3 wherein R3 has the meanings given above for R2, and the resulting compound of formula
- 38
- is reduced and optionally hydrolysed.
A compound of formula
- 47
- wherein R1 is C1-C6alkyl and
- R2 is hydrogen or a hydrocarbon radical, especially C1-C6alkyl.
A compound of formula
- 55
- wherein R1 is C1-C6alkyl and
- R2 is hydrogen or a hydrocarbon radical, especially C1-C6alkyl.
A compound of formula
- 57
- wherein R1 is C1-C6alkyl, and
- R6 and R7 are hydrogen or hydrocarbon radicals, especially C1-C6alkyl.
A compound of formula
- 58
- wherein R1 is C1-C6alkyl and
- Y is bromine, chlorine or iodine, especially bromine.
Dependencies are inferred from the claim text.