Spiroazabicyclic heterocyclic compounds

A compound of formula I

• 9
• wherein n is 0 or 1;
• m is 0 or 1;
• p is 0;
• Y is CH, N or NO
• X is oxygen or sulfur;
• W is two H moieties;
• A is N or C(R2);
• G is N or C(R3);
• D is N or C(R4);
• with the proviso that no more than one of A, G, and D is nitrogen but at least one of Y, A, G, and D is nitrogen or NO;
• R1 is hydrogen or C1-C4 alkyl;
• R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R1, —CN, —NO2, —NR5R6, —CF3, —OSO2CF3, or R2 and R3, or R3 and R4, respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents:
• independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R1, —CN, —NO2, —NR5R6, —CF3, OSO2CF3;
• R5 and R6 are independently hydrogen, C1-C4 alkyl, C(O)R7, C(O)NHR8, C(O)OR9, SO2R10 or may together be (CH2)jQ(CH2)k where Q is O, S, NR11, or a bond;
• j is 2 to 7;
• k is 0 to 2;
• R7, R8, R9, R10, and R11 are independently C1-C4 alkyl, aryl, or heteroaryl;
• made by the process of deprotecting a compound of formula IIA
• 10
• by removing the borane complex from said compound of formula IIA by treating with acid in a solvent or heating in an alcoholic solvent.