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US 2003/0166933 A1Published application
Process for the racemization of chiral quinazolinones
AssigneeCytokinetics, Inc.
InventorsGustave Bergnes, Bing Yao, David Morgans, JR., Whitney W. Smith
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Abstract
Racemates are obtained from one of the enantiomers, or an enantiomerically enriched mixture, of an optically active quinazolinone derivative by reaction of the compound with an alkali alkoxide of a primary alcohol and isolation of the racemate.
Claims13
A method for the racemization of an enantiomer, or an enantiomerically enriched mixture of a compound of formula,
- 11
- wherein said method comprises the steps of:
- contacting said compound with an alkali alkoxide of a C1-C6 primary alcohol;
- and
- isolating the resulting racemic compound, wherein
- R1 is chosen from hydrogen, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, substituted alkyl, substituted aryl, substituted aralkyl, substituted heteroaryl, and substituted heteroaralkyl;
- R2 is alkyl, oxaalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, substituted alkyl, substituted aryl, substituted aralkyl, substituted heteroaryl, and substituted heteroaralkyl;
- and
- R5, R6, R7 and R8 are independently chosen from hydrogen, alkyl, alkoxy, halogen, fluoroalkyl, nitro, dialkylamino, alkylsulfonyl, alkylsulfonamido, sulfonarmidoalkyl, sulfonamidoaryl, alkylthio, carboxyalkyl, carboxamido, aminocarbonyl, aryl and heretoaryl.
6 more elements
Dependencies are inferred from the claim text.