Spiroazacyclic compounds as monoamine receptor modulators

A compound of formula I, salts and stereoisomers thereof

• 8
• wherein
• X is selected from the group consisting of CH2, CH2CH2, CH2O, OCH2, O, CH2S, SCH2, S, CH2N(RN), N(RN)CH2 and N(RN);
• wherein RN is selected from hydrogen and C1-6 alkyl;
• Y is selected from the group consisting of O and S;
• Z is absent or selected from the group consisting of CH and N;
• R1 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, optionally substituted C3-6 cycloalkyl, aryl, and heteroaryl;
• m is selected from the group consisting of 0 and 1;
• R4, R5, and R6 are independently selected from the group consisting of hydrogen, C1-6 alkyl, aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), heterocyclyl(C1-6 alkyl), hydroxy(C1-6 alkyl), amino(C1-6 alkyl), halo(C1-6 alkyl), optionally substituted C3-6 cylcoalkyl, aryl, and heteroaryl,
• wherein at least two of R4, R5, and R6 are independently selected from the group consisting of aryl(C1-6 alkyl), heteroaryl(C1-6 alkyl), and heterocyclyl(C1-6 alkyl);
• R2 and R3 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and optionally substituted C1-6 alkyl or selected such that R2 and R3 together form a ring system such that
• 9
• is selected from the group consisting of
• 10
• wherein
• R7 and R8 are independently selected from the group consisting of hydrogen, halogen, hydroxy, and C1-6 alkyl.