Trefoil domain-containing polynucleotides, polypeptides, and antibodies
AssigneeHuman Genome Sciences, Inc.
InventorsReinhard Ebner, Yanggu Shi, Steven M. Ruben
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Abstract
The present invention relates to novel human TDC polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human TDC polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human TDC polypeptides.
Claims22
An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) the polynucleotide shown as SEQ ID NO:X or the polynucleotide encoded by a cDNA included in ATCC Deposit No:Z;
- (b) a polynucleotide encoding a biologically active polypeptide fragment of SEQ ID NO:Y or a biologically active polypeptide fragment encoded by the cDNA sequence included in ATCC Deposit No:Z;
- (c) a polynucleotide encoding a polypeptide epitope of SEQ ID NO:Y or a polypeptide epitope encoded by the cDNA sequence included in ATCC Deposit No:Z;
- (d) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(c), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues.
An isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence selected from the group consisting of:
- (a) the polypeptide shown as SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- (b) a polypeptide fragment of SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- (c) a polypeptide epitope of SEQ ID NO:Y or the polypeptide encoded by the cDNA;
- and
- (d) a variant of SEQ ID NO:Y.
Dependencies are inferred from the claim text.