ADAMTS polypeptides, nucleic acids encoding them, and uses thereof
OwnerLeonard Buckbinder, Peter Geoffrey Mitchell +2inventors
InventorsLeonard Buckbinder, Peter Geoffrey Mitchell, Roderick Thomas Walsh, Timothy Scott Wachtmann
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Abstract
The present invention relates to members of the family of proteins known as ADAMTS proteins, the new members being designated ADAMTS-E polypeptides. The invention also relates to polynucleotides encoding ADAMTS-E, antibodies to ADAMTS-E, assays for studying the function of ADAMTS-E, assays for determining stimulators or inhibitors of ADAMTS-E, and to the use of ADAMTS-E polypeptides or polynucleotides in diagnostic, biotherapeutic, or gene therapy methods.
Claims18
An isolated polynucleotide molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence having at least 80% identity to a nucleotide sequence encoding an ADAMTS-E polypeptide of SEQ ID NO:
- 2 or of SEQ ID NO:
- 8, or a metalloproteinase, disintegrin domain, prodomain, or thrombospondin (TSP) motif thereof;
- (b) a nucleotide sequence of at least 15 contiguous nucleotides that hybridizes under stringent conditions to the polynucleotide molecule of SEQ ID NO:
- 1 or to the polynucleotide molecule of SEQ ID NO:
- 7;
- and
- (c) the complement of the nucleotide sequence of (a) or (b).
Dependencies are inferred from the claim text.