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US 2003/0166896 A1Published application
Base-modified enzymatic nucleic acid
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsNassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
Life of this patent
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Abstract
Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
Claims18
A compound having the general formula:
- 1
- wherein DMT is dimethoxytrityl.
A compound having the general formula:
- 2
- wherein R1 is H or acetyl and DMT is dimethoxytrityl.
A polynucleotide comprising one or more nucleotides having the general formula:
- 3
A polynucleotide comprising one or more nucleotides having the general formula:
- 4
- wherein R1 is H or acetyl.
A nucleoside phosphoramidite having a 6-methyl uridine base.
A nucleoside phosphoramidite having a 6-methyl cytidine base.
Dependencies are inferred from the claim text.