Novel genes associated with allergic hypersensitivity and mast cell activation
OwnerKarl Nocka, Gregorio Pirozzi +1inventors
InventorsKarl Nocka, Gregorio Pirozzi, Richard Einstein
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Abstract
The invention relates generally to the changes in gene expression in mast cells during maturation and in tissues removed from patients with urticaria or allergic hypersensitivity relative to gene expression in mast cells removed from normal subjects. The invention specifically relates to four novel gene families which are differentially expressed in mast cells and allergic hypersensitivity diseases, such as urticaria, compared to normal tissues.
Claims69
An isolated nucleic acid molecule selected from the group consisting of:
- (a) an isolated nucleic acid molecule that encodes the amino acid sequence of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13;
- (b) an isolated nucleic acid molecule that encodes a fragment of at least 6 amino acids of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13;
- (c) an isolated nucleic acid molecule which hybridizes to the complement of a nucleic acid molecule comprising SEQ ID NO:
- 1, 3, 6, 8, 10 or 12;
- (d) an isolated nucleic acid molecule which hybridizes to the complement of a nucleic acid molecule that encodes the amino acid sequence of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13;
- and (e) an isolated nucleic acid molecule that encodes a protein that exhibits at least about 35% amino acid sequence identity to SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13.
An isolated nucleic acid molecule selected from the group consisting of:
- (a) an isolated nucleic acid molecule that encodes the amino acid sequence of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13;
- and (b) an isolated nucleic acid molecule that encodes the polypeptide of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13.
An isolated polypeptide or protein selected from the group consisting of an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13, an isolated polypeptide comprising a fragment of at least 6 amino acids of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13, an isolated polypeptide comprising conservative amino acid substitutions of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13 or naturally occurring amino acid sequence variants of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13, and an isolated polypeptide exhibiting at least about 35% amino acid sequence identity with SEQ ID NO:
- 2, 4, 5, 7, 9, 11 or 13.
An isolated polypeptide or protein selected from the group consisting of an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, 4, 5, 7, 9, 11 and 13.
A computer system comprising
- (a) a database containing information identifying the expression level in a tissue or at least one mast cell of a set of nucleic acids comprising at least one nucleic aid sequence selected from the group consisting of SEQ ID NOs:
- 1, 3, 6, 8, 10 and 12 or a complement thereof, and
- (b) a user interface to view the information.
A computer system comprising:
- (a) a database containing information identifying the expression level in a tissue or at least one mast cell of a set of nucleic acids comprising at least one nucleic aid sequence encoding a protein selected from the group consisting of SEQ ID NOs:
- 2, 4, 5, 7, 9, 11 and 13 or a complement of said nucleic acid sequence;
- and
- (b) a user interface to view the information.
A computer system comprising:
- the nucleotide and/or amino acid sequence of at least one of SEQ ID NOs:
- 1-13 and a user interface to view the information.
Dependencies are inferred from the claim text.