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US 2003/0166873 A1Published application
VEGF-related protein
AssigneeGenentech, Inc.
InventorsJames Lee, William Wood
Life of this patent
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Abstract
A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
Claims22
A monoclonal antibody that specifically binds to amino acid residues 1 to 157 or 21 to 157 of SEQ ID NO:3.
A VRP antagonist comprising a VRP receptor fusion protein capable of binding VRP.
Dependencies are inferred from the claim text.