Human tumor necrosis factor delta and epsilon
AssigneeHuman Genome Sciences, Inc.
InventorsGuo-Liang Yu, Jian Ni, Reiner Gentz
Life of this patent
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Abstract
The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
Claims50
An isolated polypeptide comprising a first amino acid sequence that is at least 90% identical to a second amino acid sequence selected from the group consisting of:
- (a) amino acid residues 1 to 233 of SEQ ID NO:2;
- and
- (b) amino acid residues 39 to 233 of SEQ ID NO:2;
- wherein a polypeptide consisting of said first amino acid sequence is capable of stimulating the activation of a T cell.
An isolated polypeptide comprising a first amino acid sequence that is at least 90% identical to a fragment of SEQ ID NO:2 wherein said fragment is at least 30 contiguous amino acids in length, and wherein a polypeptide consisting of said first amino acid sequence is capable of stimulating the activation of a T cell.
An isolated polypeptide comprising a first amino acid sequence that is at least 90% identical to the amino acid sequence encoded by the cDNA contained in ATCC Deposit No. 97377.
An isolated polypeptide comprising a fragment of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 97377 wherein said fragment is at least 30 contiguous amino acids in length, and wherein a polypeptide consisting of said fragment is capable of stimulating the activation of a T cell.
Dependencies are inferred from the claim text.