US 2003/0166863 A1 · Macrophage migration inhibitory factor-3

Abstract

The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases. Also disclosed are diagnostic methods for detecting conditions related to a mutation in a nucleic acid sequence encoding a polypeptide of the present invention and altered levels of the polypeptide of the present invention.

Claims18

Dependent claims

An isolated polynucleotide comprising a member selected from the group consisting of:

(a) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 118 as set forth in SEQ ID NO:2;
(b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
and
(c) a polynucleotide fragment of the polynucleotide of (a) or (b).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/178,731Filed 25 Jun 2002

Priority

16 May 1994

Published

4 Sep 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07K 14/52
From animals; from humans: cytokines; Lymphokines; Interferons
A61K 38/00
Medicinal preparations containing peptides
C07K
Peptides
A61K
Medicines and medical preparations

Family

Application08/460,528Division · filed 2 Jun 1995

Application08/460,528Continuation in part · filed 2 Jun 1995

Application08/903,224Division · filed 22 Jul 1997

Application09/286,290Continuation · filed 6 Apr 1999

Application09/286,290Division · filed 6 Apr 1999

Application10/178,731Continuation · filed 25 Jun 2002

US 5,650,295 ARelated patent

US 5,986,060 ARelated patent

US 2003/0166863 A1This patent

From the US filing history. Foreign family members aren’t listed.

Macrophage migration inhibitory factor-3

Life of this patent

Macrophage migration inhibitory factor-3

Life of this patent

Abstract

Claims18