Purified mammalian CTLA-8 antigens and related reagents
AssigneeInserm (Institut National De La Sante Et De La Recherche Medicale)
InventorsPierre Golstein, Eric Rouvier, Francois Fossiez, Serge J.E. Lebecque, Odile Djossou, Jacques Banchereau
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Abstract
CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
Claims22
A nucleic acid at least 95% identical to one encoding a mammalian CTLA protein or fragment thereof.
A substantially pure primate CTLA-8 protein or peptide thereof.
An antibody which specifically binds a mammalian CTLA-8 protein or peptide thereof.
A kit comprising:
- a) a nucleic acid at least 95% identical to one encoding a mammalian CTLA-8 protein or peptide;
- b) a substantially pure mammalian CTLA-8 protein or fragment;
- or
- c) an antibody or receptor which specifically binds a mammalian CTLA-8 protein.
A method of modulating physiology or development of a cell comprising contacting said cell with an agonist or antagonist of a mammalian CTLA-8 protein.
A method of modulating CTLA-8 induced secretion of an inflammatory mediator from a cell in a tissue comprising the step of contacting said tissue with:
- a) an antibody which specifically binds to a mammalian CTLA-8;
- or
- b) a substantially pure CTLA-8 protein or peptide thereof.
Dependencies are inferred from the claim text.