Growth factor receptor binding protein
AssigneeIncyte Genomics, Inc.
InventorsOlga Bandman, Anthony P. Diegidio
Life of this patent
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Abstract
The present invention provides a human growth factor receptor binding protein (GRBP) and polynucleotides which encode GRBP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing GRBP and for treating disorders associated with expression of GRBP.
Claims57
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence of SEQ ID NO:
- 1,
- b) a polypeptide comprising a naturally occurring amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:
- 1,
- c) a biologically active fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
- 1, and
- d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
- 1.
An isolated polynucleotide encoding a polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence of SEQ ID NO:
- 1,
- b) a polypeptide comprising a naturally occurring amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:
- 1,
- c) a biologically active fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
- 1, and
- d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
- 1.
An isolated antibody which specifically binds to a polypeptide selected from the group consisting of:
- a) the amino acid sequence of SEQ ID NO:
- 1,
- b) a polypeptide comprising a naturally occurring amino acid sequence having growth factor receptor-binding activity and having at least 80% sequence identity to the complete sequence of SEQ ID NO:
- 1,
- c) a biologically-active fragment of the amino acid sequence of SEQ ID NO:
- 1 having growth factor receptor-binding activity, and
- d) an immunogenic fragment of the amino acid sequence of SEQ ID NO:
- 1 comprising at least 15 contiguous amino acid residues.
An isolated polynucleotide selected from the group consisting of:
- a) a polynucleotide comprising the polynucleotide sequence of SEQ ID NO:
- 2,
- b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to the polynucleotide sequence of SEQ ID NO:
- 2,
- c) a polynucleotide complementary to a polynucleotide of a),
- d) a polynucleotide complementary to a polynucleotide of b), and
- e) an RNA equivalent of a)-d).
Dependencies are inferred from the claim text.