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OwnerSamuel Davis, Joanne Bruno +6inventors
InventorsSamuel Davis, Joanne Bruno, Mitchell Goldfarb, Thomas H. Aldrich, Peter C. Maisonpierre, Czeslaw Radziejewski, Pamela F. Jones, George D. Yancopoulos
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The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
An isolated nucleic acid molecule encoding a TIE-2 ligand.
An isolated TIE-2 ligand substantially free of other proteins.
A TIE-2 antagonist for use in a method of inhibiting TIE-2 ligand activity in a mammal.
A ligandbody which comprises a TIE-2 ligand fused to an immunoglobulin constant region.
Dependencies are inferred from the claim text.