HIV antisense proteins
OwnerLinda B. Ludwiginventor
Life of this patent
Estimating the term…
Abstract
Disclosed is a novel HIV gene comprising a set of open reading frames encoded with the template as the plus strand of the proviral DNA, and located in the region of HIV-1 long terminal repeat. The genes encode a set of antisense proteins, (HAPs) as well as smaller proteins, related to, and containing structural motif resembling that of chemokine proteins. Depending upon the ribosomal frameshift, a plurality of proteins may be translated from the antisense RNA. The smaller proteins have similarity with chemokine SDF-1 and may play a role as a cofactor with gp120 in the binding to and entry of HIV to a target cell.
Claims16
An isolated polynucleotide encoding a HIV protein wherein the polynucleotide has a sequence comprising SEQ ID NO:
- 27.
An isolated protein having the sequence of SEQ ID NO:
- 28.
An isolated protein having the sequence of SEQ ID NO:
- 29.
An isolated polynucleotide encoding a HIV protein wherein the polynucleotide has a sequence comprising SEQ ID NO:
- 32.
An isolated protein having the sequence of SEQ ID NO:
- 30.
An isolated protein having the sequence of SEQ ID NO:
- 31.
An isolated polynucleotide encoding a HIV protein wherein the polynucleotide has a sequence comprising SEQ ID NO:
- 34.
An isolated protein having the sequence of SEQ ID NO:
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An isolated polypetide having the sequence of SEQ ID NO:
- 36.
Dependencies are inferred from the claim text.