Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
AssigneeCorvas International, Inc.
InventorsEdwin Madison, Edgar O. Ong
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Abstract
Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP9 are provided.
Claims110
A substantially purified single or two chain polypeptide, comprising the protease domain of a type-II membrane-type serine protease 9 (MTSP9) or a catalytically active portion thereof.
A method of diagnosing the presence of a pre-malignant lesion, a malignancy, or other pathologic condition in a subject, comprising:
- obtaining a biological sample from the subject;
- and
- exposing it to a detectable agent that binds to a two-chain and/or single-chain form of an MTSP9 polypeptide, wherein the pathological condition is characterized by the presence or absence of the two-chain or single-chain form.
A method of monitoring tumor progression and/or therapeutic effectiveness, comprising detecting and/or quantifying the level, the form and/or activity of an MTSP9 polypeptide in a body tissue or fluid sample.
An isolated substantially pure polypeptide that consists essentially of the protease domain of MTSP9.
Dependencies are inferred from the claim text.